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Dokumenttyp:
journal article 
Autor(en):
Zhang, L; Orban, M; Lorenz, M; Barocke, V; Braun, D; Urtz, N; Schulz, C; von Brühl, ML; Tirniceriu, A; Gaertner, F; Proia, RL; Graf, T; Bolz, SS; Montanez, E; Prinz, M; Müller, A; von Baumgarten, L; Billich, A; Sixt, M; Fässler, R; von Andrian, UH; Junt, T; Massberg, S 
Titel:
A novel role of sphingosine 1-phosphate receptor S1pr1 in mouse thrombopoiesis. 
Abstract:
Millions of platelets are produced each hour by bone marrow (BM) megakaryocytes (MKs). MKs extend transendothelial proplatelet (PP) extensions into BM sinusoids and shed new platelets into the blood. The mechanisms that control platelet generation remain incompletely understood. Using conditional mutants and intravital multiphoton microscopy, we show here that the lipid mediator sphingosine 1-phosphate (S1P) serves as a critical directional cue guiding the elongation of megakaryocytic PP extensi...    »
 
Zeitschriftentitel:
J Exp Med 
Jahr:
2012 
Band / Volume:
209 
Heft / Issue:
12 
Seitenangaben Beitrag:
2165-81 
Sprache:
eng 
Print-ISSN:
0022-1007 
TUM Einrichtung:
r Herz- und Kreislauferkrankungen