User: Guest  Login
Document type:
journal article 
Author(s):
Gutermuth, J; Nograles, KE; Miyagawa, F; Nelson, E; Cho, YH; Katz, SI 
Title:
Self-peptides prolong survival in murine autoimmunity via reduced IL-2/IL-7-mediated STAT5 signaling, CD8 coreceptor, and V alpha 2 down-regulation. 
Abstract:
Although the pathogenic role of B cells and CD4 T cells has been studied extensively, less is known about the role of CD8 T cells in autoimmunity and self-tolerance. To evaluate the role of CD8 T cells in autoimmunity and its modulation using self-peptides, we used mice expressing soluble OVA (sOVA) under control of the keratin-14 promoter. Spontaneous autoimmunity occurred when sOVA mice were crossed with OT-I mice, whose CD8 T cells carry a Valpha2/Vbeta5-transgenic TCR with specificity for th...    »
 
Journal title abbreviation:
J Immunol 
Year:
2009 
Journal volume:
183 
Journal issue:
Pages contribution:
3130-8 
Language:
eng 
Print-ISSN:
0022-1767 
TUM Institution:
Institut für Molekulare Allergologie und Umweltforschung