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Document type:
journal article 
Author(s):
Provoost, S; Maes, T; van Durme, YM; Gevaert, P; Bachert, C; Schmidt-Weber, CB; Brusselle, GG; Joos, GF; Tournoy, KG 
Title:
Decreased FOXP3 protein expression in patients with asthma. 
Abstract:
T-regulatory cells (T(reg)) are important in balancing immune responses and maintaining peripheral tolerance. Current evidence suggests that asthma is characterized by a relative deficiency in T(reg), allowing T helper 2 cells to expand. In this study, we aimed to evaluate circulating T(reg), defined by the protein FOXP3, in both control subjects and patients with stable asthma.Peripheral blood mononuclear cells (PBMC) of control (n = 14) and asthmatic patients (n = 29) were labeled for CD4, CD2...    »
 
Journal title abbreviation:
Allergy 
Year:
2009 
Journal volume:
64 
Journal issue:
10 
Pages contribution:
1539-46 
Language:
eng 
Print-ISSN:
0105-4538 
TUM Institution:
Institut für Molekulare Allergologie und Umweltforschung