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Dokumenttyp:
journal article 
Autor(en):
Buters, JT; Mahadevan, B; Quintanilla-Martinez, L; Gonzalez, FJ; Greim, H; Baird, WM; Luch, A 
Titel:
Cytochrome P450 1B1 determines susceptibility to dibenzo[a,l]pyrene-induced tumor formation. 
Abstract:
Metabolic activation, DNA binding, and tumorigenicity of the carcinogenic polycyclic aromatic hydrocarbon dibenzo[a,l]pyrene (DB[a,l]P) catalyzed by murine cytochrome P450 (P450) enzymes were investigated. DNA binding of DB[a,l]P in human mammary carcinoma MCF-7 and human P450-expressing Chinese hamster V79 cell lines was previously shown to occur preferentially with metabolically generated fjord region DB[a,l]P-11,12-dihydrodiol 13,14-epoxides (DB[a,l]PDE). To elucidate different capabilities o...    »
 
Zeitschriftentitel:
Chem Res Toxicol 
Jahr:
2002 
Band / Volume:
15 
Heft / Issue:
Seitenangaben Beitrag:
1127-35 
Sprache:
eng 
Print-ISSN:
0893-228X 
TUM Einrichtung:
r Molekulare Allergologie und Umweltforschung