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Dokumenttyp:
journal article 
Autor(en):
Luch, A; Greim, H; Buters, JTM; Mahadevan, B; Baird, WM; Doehmer, J; Seidel, A; Glatt, H 
Titel:
The role of cytochrome P4501B1 in dibenzo[a,l]lipyrene-induced carcinogenesis 
Abstract:
In human cells, the most carcinogenic polycyclic aromatic hydrocarbon dibenzo[a,1]pyrene (DB[a,1]P) forms high levels of DNA adducts through formation of the (-)-anti-(11R,12S)-diol (13S,14R)-epoxide (DB[a,1]PDE) and its metabolic precursor, the (-)-(11R,12R)-diol. Generation of these adducts results from the catalytic activity of cytochrome P450 (P450) 1A1 and 1B1. Additional adducts such as (+)-syn-DB[a,1]PDE-DNA or more polar DNA adducts were detected only after increasing exposure doses of t...    »
 
Zeitschriftentitel:
Polycycl Aromat Compd 
Jahr:
2002 
Band / Volume:
22 
Heft / Issue:
3-4 
Seitenangaben Beitrag:
781-789 
Sprache:
eng 
Print-ISSN:
1040-6638 
TUM Einrichtung:
r Molekulare Allergologie und Umweltforschung