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Document type:
journal article 
Author(s):
Krausz, KW; Goldfarb, I; Buters, JT; Yang, TJ; Gonzalez, FJ; Gelboin, HV 
Title:
Monoclonal antibodies specific and inhibitory to human cytochromes P450 2C8, 2C9, and 2C19. 
Abstract:
Hybridomas were isolated that produce 13 monoclonal antibodies (mAbs) that are specific and highly inhibitory to members of the human P450 2C subfamily, 2C8, 2C9, 2C9*2, and 2C19. Many of the mAbs to P450 2C8, 2C9, and 2C19 are specific and exhibit potent inhibitory activity (85-95%). mAb 281-1-1 specifically binds, immunoblots, and strongly inhibits the activity of P450 2C8. mAb 763-15-5 specifically binds and strongly inhibits the activity of P450 2C9. mAb 1-7-4-8 specifically binds and strong...    »
 
Journal title abbreviation:
Drug Metab Dispos 
Year:
2001 
Journal volume:
29 
Journal issue:
11 
Pages contribution:
1410-23 
Language:
eng 
Print-ISSN:
0090-9556 
TUM Institution:
Institut für Molekulare Allergologie und Umweltforschung