User: Guest  Login
Document type:
journal article 
Author(s):
Deenick, EK; Po, L; Chapatte, L; Murakami, K; Lu, YC; Elford, AR; Saibil, SD; Ruland, J; Gerondakis, S; Mak, TW; Ohashi, PS 
Title:
c-Rel phenocopies PKCtheta but not Bcl-10 in regulating CD8+ T-cell activation versus tolerance. 
Abstract:
Elucidating the signaling events that promote T-cell tolerance versus activation provides important insights for manipulating immunity in vivo. Previous studies have suggested that the absence of PKCtheta results in the induction of anergy and that the balance between the induction of the transcription factors NFAT, AP1 and NF-kappaB plays a key role in determining whether T-cell anergy or activation is induced. Here, we examine whether Bcl-10 and specific family members of NF-kappaB act downstr...    »
 
Journal title abbreviation:
Eur J Immunol 
Year:
2010 
Journal volume:
40 
Journal issue:
Pages contribution:
867-77 
Language:
eng 
Print-ISSN:
0014-2980 
TUM Institution:
Institut für Molekulare Immunologie