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Document type:
journal article 
Author(s):
Silva, A; Weber, A; Bain, M; Reding, T; Heikenwalder, M; Sonda, S; Graf, R 
Title:
COX-2 is not required for the development of murine chronic pancreatitis. 
Abstract:
Chronic pancreatitis is a severe inflammation of the pancreas associated with destruction of the parenchyma, fibrosis, and persistent abdominal pain. Cyclooxygenase-2 (COX-2) and COX-2-derived prostaglandins, key mediators of the inflammatory response, are elevated in patients with chronic pancreatitis. Previous studies investigated COX-2 as a therapeutic target. These reports showed a reduced pathology in COX-2-deficient mice with a better outcome. Here we compared the role of COX-2 in acute an...    »
 
Journal title abbreviation:
Am J Physiol Gastrointest Liver Physiol 
Year:
2011 
Journal volume:
300 
Journal issue:
Pages contribution:
G968-75 
Language:
eng 
Print-ISSN:
0193-1857 
TUM Institution:
Institut für Virologie