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Dokumenttyp:
journal article 
Autor(en):
Silva, A; Weber, A; Bain, M; Reding, T; Heikenwalder, M; Sonda, S; Graf, R 
Titel:
COX-2 is not required for the development of murine chronic pancreatitis. 
Abstract:
Chronic pancreatitis is a severe inflammation of the pancreas associated with destruction of the parenchyma, fibrosis, and persistent abdominal pain. Cyclooxygenase-2 (COX-2) and COX-2-derived prostaglandins, key mediators of the inflammatory response, are elevated in patients with chronic pancreatitis. Previous studies investigated COX-2 as a therapeutic target. These reports showed a reduced pathology in COX-2-deficient mice with a better outcome. Here we compared the role of COX-2 in acute an...    »
 
Zeitschriftentitel:
Am J Physiol Gastrointest Liver Physiol 
Jahr:
2011 
Band / Volume:
300 
Heft / Issue:
Seitenangaben Beitrag:
G968-75 
Sprache:
eng 
Print-ISSN:
0193-1857 
TUM Einrichtung:
r Virologie