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Dokumenttyp:
journal article 
Autor(en):
Greenwood, AD; Horsch, M; Stengel, A; Vorberg, I; Lutzny, G; Maas, E; Schädler, S; Erfle, V; Beckers, J; Schätzl, H; Leib-Mösch, C 
Titel:
Cell line dependent RNA expression profiles of prion-infected mouse neuronal cells. 
Abstract:
The overall impact of prion disease on gene expression is not well characterized. We have carried out a large-scale expression analysis of specific cell types commonly employed in studies of prion disease. Neuroblastoma cells (N2a) and hypothalamic neuronal cells (GT1) can be persistently infected with mouse-adapted scrapie prions, the latter demonstrating cytopathologic effects associated with prion neuropathology. Exploiting a mouse DNA microarray containing approximately 21,000 spotted cDNAs,...    »
 
Zeitschriftentitel:
J Mol Biol 
Jahr:
2005 
Band / Volume:
349 
Heft / Issue:
Seitenangaben Beitrag:
487-500 
Sprache:
eng 
Print-ISSN:
0022-2836 
TUM Einrichtung:
r Virologie