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Dokumenttyp:
journal article 
Autor(en):
Nawroth, R; Stellwagen, F; Schulz, WA; Stoehr, R; Hartmann, A; Krause, BJ; Gschwend, JE; Retz, M 
Titel:
S6K1 and 4E-BP1 are independent regulated and control cellular growth in bladder cancer. 
Abstract:
Aberrant activation and mutation status of proteins in the phosphatidylinositol-3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) and the mitogen activated protein kinase (MAPK) signaling pathways have been linked to tumorigenesis in various tumors including urothelial carcinoma (UC). However, anti-tumor therapy with small molecule inhibitors against mTOR turned out to be less successful than expected. We characterized the molecular mechanism of this pathway in urothelial carcinoma by int...    »
 
Zeitschriftentitel:
PLoS ONE 
Jahr:
2011 
Band / Volume:
Heft / Issue:
11 
Seitenangaben Beitrag:
e27509 
Sprache:
eng 
TUM Einrichtung:
Urologische Klinik und Poliklinik