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Dokumenttyp:
journal article 
Autor(en):
Lux, C; Albiez, H; Chapman, RD; Heidinger, M; Meininghaus, M; Brack-Werner, R; Lang, A; Ziegler, M; Cremer, T; Eick, D 
Titel:
Transition from initiation to promoter proximal pausing requires the CTD of RNA polymerase II. 
Abstract:
The C-terminal domain (CTD) of mammalian RNA polymerase II consists of 52 repeats of the consensus hepta-peptide YSPTSPS, and links transcription to the processing of pre-mRNA. Although Pol II with a CTD shortened to five repeats (Pol II Delta5) is transcriptionally inactive on chromatin templates, it is not clear whether CTD is required for promoter recognition in vivo. Here, we demonstrate that in the context of chromatin, Pol II Delta5 can bind to the c-myc promoter with the same efficiency a...    »
 
Zeitschriftentitel:
Nucleic Acids Res 
Jahr:
2005 
Band / Volume:
33 
Heft / Issue:
16 
Seitenangaben Beitrag:
5139-44 
Sprache:
eng 
Print-ISSN:
0305-1048 
TUM Einrichtung:
Urologische Klinik und Poliklinik