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Document type:
journal article 
Author(s):
Zhu, P; Huber, E; Kiefer, F; Göttlicher, M 
Title:
Specific and redundant functions of histone deacetylases in regulation of cell cycle and apoptosis. 
Abstract:
Inappropriate control of expression of genetic information is the cause of many forms of cancer. Aberrant transcriptional repression by recruitment of histone deacetylases (HDACs) is a key step in pathogenesis of myeloid leukemia. We recently reported that development of colonic cancer involves alterations in the transcriptional repression machinery by increased expression of HDAC2 upon loss of the APC tumor suppressor. Increased expression of HDAC2 is essential for prevention of apoptosis of HT...    »
 
Journal title abbreviation:
Cell Cycle 
Year:
2004 
Journal volume:
Journal issue:
10 
Pages contribution:
1240-2 
Language:
eng 
Print-ISSN:
1538-4101 
TUM Institution:
Institut für Toxikologie und Umwelthygiene