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Dokumenttyp:
journal article 
Autor(en):
Göttlicher, M 
Titel:
Valproic acid: an old drug newly discovered as inhibitor of histone deacetylases. 
Abstract:
Fusion proteins encoded by several types of chromosomal translocations in promyelocytic leukemia can serve as aberrant transcriptional repressors relying on recruitment of histonedeacetylases (HDACs) into DNA-associated multi-protein complexes. Thus, inappropriate modulation of chromatin structure by HDACs and subsequently repression of gene expression that is critical for myeloid differentiation appear to be major factors in the development of the disease. They identify inhibitors of HDACs as p...    »
 
Zeitschriftentitel:
Ann Hematol 
Jahr:
2004 
Band / Volume:
83 Suppl 1 
Seitenangaben Beitrag:
S91-2 
Sprache:
eng 
Print-ISSN:
0939-5555 
TUM Einrichtung:
r Toxikologie und Umwelthygiene