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Dokumenttyp:
journal article 
Autor(en):
Krämer, OH; Zhu, P; Ostendorff, HP; Golebiewski, M; Tiefenbach, J; Peters, MA; Brill, B; Groner, B; Bach, I; Heinzel, T; Göttlicher, M 
Titel:
The histone deacetylase inhibitor valproic acid selectively induces proteasomal degradation of HDAC2. 
Abstract:
Histone-modifying enzymes play essential roles in physiological and aberrant gene regulation. Since histone deacetylases (HDACs) are promising targets of cancer therapy, it is important to understand the mechanisms of HDAC regulation. Selective modulators of HDAC isoenzymes could serve as efficient and well-tolerated drugs. We show that HDAC2 undergoes basal turnover by the ubiquitin-proteasome pathway. Valproic acid (VPA), in addition to selectively inhibiting the catalytic activity of class I...    »
 
Zeitschriftentitel:
EMBO J 
Jahr:
2003 
Band / Volume:
22 
Heft / Issue:
13 
Seitenangaben Beitrag:
3411-20 
Sprache:
eng 
Print-ISSN:
0261-4189 
TUM Einrichtung:
r Toxikologie und Umwelthygiene