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Dokumenttyp:
journal article 
Autor(en):
Braren, R; Hu, H; Kim, YH; Beggs, HE; Reichardt, LF; Wang, R 
Titel:
Endothelial FAK is essential for vascular network stability, cell survival, and lamellipodial formation. 
Abstract:
Morphogenesis of a vascular network requires dynamic vessel growth and regression. To investigate the cellular mechanism underlying this process, we deleted focal adhesion kinase (FAK), a key signaling mediator, in endothelial cells (ECs) using Tie2-Cre mice. Targeted FAK depletion occurred efficiently early in development, where mutants exhibited a distinctive and irregular vasculature, resulting in hemorrhage and lethality between embryonic day (e) 10.5 and 11.5. Capillaries and intercapillary...    »
 
Zeitschriftentitel:
J Cell Biol 
Jahr:
2006 
Band / Volume:
172 
Heft / Issue:
Seitenangaben Beitrag:
151-62 
Sprache:
eng 
Print-ISSN:
0021-9525 
TUM Einrichtung:
r Radiologie