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Dokumenttyp:
journal article 
Autor(en):
Depboylu, C; Du, Y; Müller, U; Kurz, A; Zimmer, R; Riemenschneider, M; Gasser, T; Oertel, WH; Klockgether, T; Dodel, RC; Oertelf, WH 
Titel:
Lack of association of interleukin-10 promoter region polymorphisms with Alzheimer's disease. 
Abstract:
There is increasing evidence that immune mechanisms are involved in the pathogenesis of Alzheimer's disease (AD). Recently, polymorphisms of the interleukin (IL)-1 and IL-6 genes were found to be associated with late-onset AD. The immunoregulatory IL-10 downregulates synthesis of pro-inflammatory cytokines such as IL-1. Current evidence suggests that some polymorphisms in the IL-10 promoter may have functional effects on IL-10 transcription. A total of 406 German AD patients (mean age 70.2+/-10....    »
 
Zeitschriftentitel:
Neurosci Lett 
Jahr:
2003 
Band / Volume:
342 
Heft / Issue:
1-2 
Seitenangaben Beitrag:
132-4 
Sprache:
eng 
Print-ISSN:
0304-3940 
TUM Einrichtung:
r Psychiatrie und Psychotherapie