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Dokumenttyp:
journal article 
Autor(en):
Cattaruzza, M; Guzik, TJ; S?odowski, W; Pelvan, A; Becker, J; Halle, M; Buchwald, AB; Channon, KM; Hecker, M 
Titel:
Shear stress insensitivity of endothelial nitric oxide synthase expression as a genetic risk factor for coronary heart disease. 
Abstract:
Coronary heart disease (CHD) is based on the development of atherosclerosis in coronary arteries. Shear stress-induced endothelial nitric oxide (NO) release not only contributes to local blood pressure control but also effectively helps to retard atherosclerosis. Therefore, functionally relevant polymorphisms in the endothelial NO synthase (NOS-3) gene may contribute to the development of CHD. NOS-3 expression was analyzed in endothelial cells isolated from umbilical cords genotyped for the -786...    »
 
Zeitschriftentitel:
Circ Res 
Jahr:
2004 
Band / Volume:
95 
Heft / Issue:
Seitenangaben Beitrag:
841-7 
Sprache:
eng 
Print-ISSN:
0009-7330 
TUM Einrichtung:
ventive und rehabilitative Sportmedizin