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Document type:
journal article 
Author(s):
Cattaruzza, M; Guzik, TJ; S?odowski, W; Pelvan, A; Becker, J; Halle, M; Buchwald, AB; Channon, KM; Hecker, M 
Title:
Shear stress insensitivity of endothelial nitric oxide synthase expression as a genetic risk factor for coronary heart disease. 
Abstract:
Coronary heart disease (CHD) is based on the development of atherosclerosis in coronary arteries. Shear stress-induced endothelial nitric oxide (NO) release not only contributes to local blood pressure control but also effectively helps to retard atherosclerosis. Therefore, functionally relevant polymorphisms in the endothelial NO synthase (NOS-3) gene may contribute to the development of CHD. NOS-3 expression was analyzed in endothelial cells isolated from umbilical cords genotyped for the -786...    »
 
Journal title abbreviation:
Circ Res 
Year:
2004 
Journal volume:
95 
Journal issue:
Pages contribution:
841-7 
Language:
eng 
Print-ISSN:
0009-7330 
TUM Institution:
ventive und rehabilitative Sportmedizin