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Dokumenttyp:
journal article 
Autor(en):
Ertl, C; Lukowski, R; Sigl, K; Schlossmann, J; Hofmann, F; Wegener, JW 
Titel:
Kinetics of relaxation by cGMP/cGKI signaling in fundus smooth muscle. 
Abstract:
cGMP-dependent kinase I (cGKI) is a major mediator of smooth muscle relaxation and exists in two isoforms, ? and ?. Both isoforms are supposed to mediate their effects via different intracellular signaling pathways. To verify this concept, the kinetics of relaxation mediated by either isoform was analyzed in gastric fundus smooth muscle from mice. Muscles from mice that express selectively the I? or I? isoform of cGKI in smooth muscle (sm-cGKI? or sm-cGKI? mice) were compared to muscles from con...    »
 
Zeitschriftentitel:
Eur J Pharmacol 
Jahr:
2011 
Band / Volume:
670 
Heft / Issue:
Seitenangaben Beitrag:
266-71 
Sprache:
eng 
Print-ISSN:
0014-2999 
TUM Einrichtung:
r Pharmakologie und Toxikologie