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Document type:
journal article 
Author(s):
Lee, TS; Karl, R; Moosmang, S; Lenhardt, P; Klugbauer, N; Hofmann, F; Kleppisch, T; Welling, A 
Title:
Calmodulin kinase II is involved in voltage-dependent facilitation of the L-type Cav1.2 calcium channel: Identification of the phosphorylation sites. 
Abstract:
Calcium-dependent facilitation of L-type calcium channels has been reported to depend on the function of calmodulin kinase II. In contrast, the mechanism for voltage-dependent facilitation is not clear. In HEK 293 cells expressing Ca(v)1.2, Ca(v)beta2a, and calmodulin kinase II, the calcium current measured at +30 mV was facilitated up to 1.5-fold by a 200-ms-long prepulse to +160 mV. This voltage-dependent facilitation was prevented by the calmodulin kinase II inhibitors KN93 and the autocamtid...    »
 
Journal title abbreviation:
J Biol Chem 
Year:
2006 
Journal volume:
281 
Journal issue:
35 
Pages contribution:
25560-7 
Language:
eng 
Print-ISSN:
0021-9258 
TUM Institution:
Institut für Pharmakologie und Toxikologie