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Document type:
journal article 
Author(s):
Boesten, LS; Zadelaar, SM; De Clercq, S; Francoz, S; van Nieuwkoop, A; Biessen, EA; Hofmann, F; Feil, S; Feil, R; Jochemsen, AG; Zurcher, C; Havekes, LM; van Vlijmen, BJ; Marine, JC 
Title:
Mdm2, but not Mdm4, protects terminally differentiated smooth muscle cells from p53-mediated caspase-3-independent cell death. 
Abstract:
p53 is a potent inhibitor of cell growth and an inducer of apoptosis. During embryonic development, Mdm2 and Mdm4 inhibit the growth suppressive activities of p53. However, whether tight surveillance of p53 activity is required in quiescent cells is unknown. To test this, conditional inactivation of mdm2 and mdm4 was carried out in smooth muscle cells (SMCs). Upon SMC-specific inactivation of mdm2, and not of mdm4, mice rapidly became ill and died. Necropsy showed small intestinal dilation, and...    »
 
Journal title abbreviation:
Cell Death Differ 
Year:
2006 
Journal volume:
13 
Journal issue:
12 
Pages contribution:
2089-98 
Language:
eng 
Print-ISSN:
1350-9047 
TUM Institution:
Institut für Pharmakologie und Toxikologie