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Document type:
journal article 
Author(s):
Stieber, J; Wieland, K; Stöckl, G; Ludwig, A; Hofmann, F 
Title:
Bradycardic and proarrhythmic properties of sinus node inhibitors. 
Abstract:
Sinus node inhibitors reduce the heart rate presumably by blocking the pacemaker current If in the cardiac conduction system. This pacemaker current is carried by four hyperpolarization-activated, cyclic nucleotide-gated cation (HCN) channels. We tested the potential subtype-specificity of the sinus node inhibitors cilobradine, ivabradine, and zatebradine using cloned HCN channels. All three substances blocked the slow inward current through human HCN1, HCN2, HCN3, and HCN4 channels. There was n...    »
 
Journal title abbreviation:
Mol Pharmacol 
Year:
2006 
Journal volume:
69 
Journal issue:
Pages contribution:
1328-37 
Language:
eng 
Print-ISSN:
0026-895X 
TUM Institution:
Institut für Pharmakologie und Toxikologie