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Document type:
journal article 
Author(s):
Moosmang, S; Haider, N; Brüderl, B; Welling, A; Hofmann, F 
Title:
Antihypertensive effects of the putative T-type calcium channel antagonist mibefradil are mediated by the L-type calcium channel Cav1.2. 
Abstract:
The role of T-type Ca2+ channels for cardiovascular physiology, in particular blood pressure regulation, is controversial. Selective blockade of T-type Ca2+ channels in resistance arteries has been proposed to explain the effect of the antihypertensive drug mibefradil. In the present study, we used a third generation, time- and tissue-specific conditional knockout model of the L-type Ca2+ channel Cav1.2 (Cav1.2SMAKO mice) to genetically dissect the effects of mibefradil on T- and L-type Ca2+ cha...    »
 
Journal title abbreviation:
Circ Res 
Year:
2006 
Journal volume:
98 
Journal issue:
Pages contribution:
105-10 
Language:
eng 
Print-ISSN:
0009-7330 
TUM Institution:
Institut für Pharmakologie und Toxikologie