User: Guest  Login
Document type:
journal article 
Author(s):
Hofmann, F; Feil, R; Kleppisch, T; Schlossmann, J 
Title:
Function of cGMP-dependent protein kinases as revealed by gene deletion. 
Abstract:
Over the past few years, a wealth of biochemical and functional data have been gathered on mammalian cGMP-dependent protein kinases (cGKs). In mammals, three different kinases are encoded by two genes. Mutant and chimeric cGK proteins generated by molecular biology techniques yielded important biochemical knowledge, such as the function of the NH(2)-terminal domains of cGKI and cGKII, the identity of the cGMP-binding sites of cGKI, and the substrate specificity of the enzymes. Genetic approaches...    »
 
Journal title abbreviation:
Physiol Rev 
Year:
2006 
Journal volume:
86 
Journal issue:
Pages contribution:
1-23 
Language:
eng 
Print-ISSN:
0031-9333 
TUM Institution:
Institut für Pharmakologie und Toxikologie