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Document type:
journal article 
Author(s):
Döring, B; Shynlova, O; Tsui, P; Eckardt, D; Janssen-Bienhold, U; Hofmann, F; Feil, S; Feil, R; Lye, SJ; Willecke, K 
Title:
Ablation of connexin43 in uterine smooth muscle cells of the mouse causes delayed parturition. 
Abstract:
Gap junctions are characteristically increased in the myometrium during term and preterm delivery and are thought to be essential for the development of uterine contractions during labour. Expression of connexin43 (Cx43), the major myometrial gap junction protein, is increased during delivery. We have generated a mouse mutant (Cx43fl/fl:SM-CreERT2), in which the coding region of Cx43 can be specifically deleted in smooth muscle cells at any given time point by application of tamoxifen. By this a...    »
 
Journal title abbreviation:
J Cell Sci 
Year:
2006 
Journal volume:
119 
Journal issue:
Pt 9 
Pages contribution:
1715-22 
Language:
eng 
Print-ISSN:
0021-9533 
TUM Institution:
Institut für Pharmakologie und Toxikologie