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Document type:
journal article 
Author(s):
Gomes, B; Savignac, M; Cabral, MD; Paulet, P; Moreau, M; Leclerc, C; Feil, R; Hofmann, F; Guéry, JC; Dietrich, G; Pelletier, L 
Title:
The cGMP/protein kinase G pathway contributes to dihydropyridine-sensitive calcium response and cytokine production in TH2 lymphocytes. 
Abstract:
Th2 lymphocytes differ from other CD4+ T lymphocytes not only by their effector tasks but also by their T cell receptor (TCR)-dependent signaling pathways. We previously showed that dihydropyridine receptors (DHPR) involved in TCR-induced calcium inflow were selectively expressed in Th2 cells. In this report, we studied whether cGMP-dependent protein kinase G (PKG) activation was implicated in the regulation of DHPR-dependent calcium response and cytokine production in Th2 lymphocytes. The contr...    »
 
Journal title abbreviation:
J Biol Chem 
Year:
2006 
Journal volume:
281 
Journal issue:
18 
Pages contribution:
12421-7 
Language:
eng 
Print-ISSN:
0021-9258 
TUM Institution:
Institut für Pharmakologie und Toxikologie