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Dokumenttyp:
journal article 
Autor(en):
Welling, A; Hofmann, F; Wegener, JW 
Titel:
Inhibition of L-type Cav1.2 Ca2+ channels by 2,(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002) and 2-[1-(3-dimethyl-aminopropyl)-5-methoxyindol-3-yl]-3-(1H-indol-3-yl) maleimide (Go6983). 
Abstract:
Phosphatidylinositol 3-kinase (PI3-K) is involved in physiological processes of cellular proliferation and inflammation and, as postulated recently, in the regulation of L-type Ca(2+) channels. The latter conclusion arose in part from the inhibitory action of the compound 2,(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002), which has been established as a selective PI3-K inhibitor (IC(50) = 1.4 microM). Herein we show, however, that LY294002 and an inhibitor of protein kinase C (PKC), 2-...    »
 
Zeitschriftentitel:
Mol Pharmacol 
Jahr:
2005 
Band / Volume:
67 
Heft / Issue:
Seitenangaben Beitrag:
541-4 
Sprache:
eng 
Print-ISSN:
0026-895X 
TUM Einrichtung:
r Pharmakologie und Toxikologie