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Dokumenttyp:
journal article 
Autor(en):
Michalakis, S; Geiger, H; Haverkamp, S; Hofmann, F; Gerstner, A; Biel, M 
Titel:
Impaired opsin targeting and cone photoreceptor migration in the retina of mice lacking the cyclic nucleotide-gated channel CNGA3. 
Abstract:
PURPOSE: To characterize molecular and cellular changes in the mouse retina caused by the genetic deletion of the cone cyclic nucleotide-gated channel (CNG) subunit CNGA3. METHODS: Retinas of wild-type and CNGA3-deficient (CNGA3(-/-)) mice from 9 days up to 22 months of age were analyzed by immunohistochemistry, electron microscopy, and molecular biological methods. RESULTS: CNGA3(-/-) cones failed to transport opsins into outer segments, downregulated various proteins of the phototransduction c...    »
 
Zeitschriftentitel:
Invest Ophthalmol Vis Sci 
Jahr:
2005 
Band / Volume:
46 
Heft / Issue:
Seitenangaben Beitrag:
1516-24 
Sprache:
eng 
Print-ISSN:
0146-0404 
TUM Einrichtung:
r Pharmakologie und Toxikologie