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Document type:
journal article 
Author(s):
Stieber, J; Stöckl, G; Herrmann, S; Hassfurth, B; Hofmann, F 
Title:
Functional expression of the human HCN3 channel. 
Abstract:
Hyperpolarization-activated, cyclic nucleotide-gated cation (HCN) channels underlie the inward pacemaker current, termed I(f)/I(h), in a variety of tissues. Many details are known for the HCN subtypes 1, 2, and 4. We now successfully cloned the cDNA for HCN3 from human brain and compared the electrophysiological properties of hHCN3 to the other three HCN subtypes. Overexpression of human HCN3 channels in HEK293 cells resulted in a functional channel protein. Similar to hHCN2 channels, hHCN3 chan...    »
 
Journal title abbreviation:
J Biol Chem 
Year:
2005 
Journal volume:
280 
Journal issue:
41 
Pages contribution:
34635-43 
Language:
eng 
Print-ISSN:
0021-9258 
TUM Institution:
Institut für Pharmakologie und Toxikologie