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Dokumenttyp:
journal article 
Autor(en):
Geiselhöringer, A; Gaisa, M; Hofmann, F; Schlossmann, J 
Titel:
Distribution of IRAG and cGKI-isoforms in murine tissues. 
Abstract:
cGMP kinase I (cGKI) signaling modulates multiple physiological processes including smooth muscle relaxation. The expression of cGKI and its substrate IRAG (Inositol 1,4,5-trisphosphate receptor associated cGMP kinase substrate) was studied. IRAG and cGKI were colocalized in the smooth muscle of aorta and colon. IRAG was present in the thalamus and in most of the myenteric plexus in the absence of cGKI. Coexpression of IRAG and cGKIbeta or cGKIalpha in COS-7 cells revealed that IRAG recruits cGK...    »
 
Zeitschriftentitel:
FEBS Lett 
Jahr:
2004 
Band / Volume:
575 
Heft / Issue:
1-3 
Seitenangaben Beitrag:
19-22 
Sprache:
eng 
Print-ISSN:
0014-5793 
TUM Einrichtung:
r Pharmakologie und Toxikologie