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Dokumenttyp:
journal article 
Autor(en):
Wegener, JW; Schulla, V; Lee, TS; Koller, A; Feil, S; Feil, R; Kleppisch, T; Klugbauer, N; Moosmang, S; Welling, A; Hofmann, F 
Titel:
An essential role of Cav1.2 L-type calcium channel for urinary bladder function. 
Abstract:
Mice deficient in the smooth muscle Cav1.2 calcium channel (SMACKO, smooth muscle alpha1c-subunit calcium channel knockout) have a severely reduced micturition and an increased bladder mass. L-type calcium current, protein, and spontaneous contractile activity were absent in the bladder of SMACKO mice. K+ and carbachol (CCh)-induced contractions were reduced to 10-fold in detrusor muscles from SMACKO mice. The dihydropyridine isradipine inhibited K+- and CCh-induced contractions of muscles from...    »
 
Zeitschriftentitel:
FASEB J 
Jahr:
2004 
Band / Volume:
18 
Heft / Issue:
10 
Seitenangaben Beitrag:
1159-61 
Sprache:
eng 
Print-ISSN:
0892-6638 
TUM Einrichtung:
r Pharmakologie und Toxikologie