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Document type:
journal article 
Author(s):
Marshall, SJ; Senis, YA; Auger, JM; Feil, R; Hofmann, F; Salmon, G; Peterson, JT; Burslem, F; Watson, SP 
Title:
GPIb-dependent platelet activation is dependent on Src kinases but not MAP kinase or cGMP-dependent kinase. 
Abstract:
Glycoprotein Ib-IX-V (GPIb-IX-V) mediates platelet tethering to von Willebrand factor (VWF), recruiting platelets into the thrombus, and activates integrin alphaIIbbeta3 through a pathway that is dependent on Src kinases. In addition, recent reports indicate that activation of alphaIIbbeta3 by VWF is dependent on protein kinase G (PKG) and mitogen-activated protein (MAP) kinases. The present study compares the importance of these signaling pathways in the activation of alphaIIbbeta3 by GPIb-IX-V...    »
 
Journal title abbreviation:
Blood 
Year:
2004 
Journal volume:
103 
Journal issue:
Pages contribution:
2601-9 
Language:
eng 
Print-ISSN:
0006-4971 
TUM Institution:
Institut für Pharmakologie und Toxikologie