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Document type:
journal article 
Author(s):
Talavera, K; Janssens, A; Klugbauer, N; Droogmans, G; Nilius, B 
Title:
Pore structure influences gating properties of the T-type Ca2+ channel alpha1G. 
Abstract:
The selectivity filter of all known T-type Ca2+ channels is built by an arrangement of two glutamate and two aspartate residues, each one located in the P-loops of domains I-IV of the alpha1 subunit (EEDD locus). The mutations of the aspartate residues to glutamate induce changes in the conduction properties, enhance Cd2+ and proton affinities, and modify the activation curve of the channel. Here we further analyze the role of the selectivity filter in the gating mechanisms of T-type channels by...    »
 
Journal title abbreviation:
J Gen Physiol 
Year:
2003 
Journal volume:
121 
Journal issue:
Pages contribution:
529-40 
Language:
eng 
Print-ISSN:
0022-1295 
TUM Institution:
Institut für Pharmakologie und Toxikologie