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Document type:
journal article 
Author(s):
Engel, C; Forberg, J; Holinski-Feder, E; Pagenstecher, C; Plaschke, J; Kloor, M; Poremba, C; Pox, CP; Rüschoff, J; Keller, G; Dietmaier, W; Rümmele, P; Friedrichs, N; Mangold, E; Buettner, R; Schackert, HK; Kienle, P; Stemmler, S; Moeslein, G; Loeffler, M; German HNPCC Consortium 
Title:
Novel strategy for optimal sequential application of clinical criteria, immunohistochemistry and microsatellite analysis in the diagnosis of hereditary nonpolyposis colorectal cancer. 
Abstract:
Clinical criteria, microsatellite analysis (MSA) and immunohistochemistry (IHC) are important diagnostic tools for identification of hereditary nonpolyposis colorectal cancer (HNPCC) patients who are likely to carry pathogenic germline mutations in mismatch repair genes. Based on MSA and IHC results and subsequent mutation analyses of 1,119 unrelated index patients meeting the Amsterdam II criteria or the classical Bethesda guidelines, we analyzed the value of these tools to predict MLH1 and MSH...    »
 
Journal title abbreviation:
Int J Cancer 
Year:
2006 
Journal volume:
118 
Journal issue:
Pages contribution:
115-22 
Language:
eng 
Print-ISSN:
0020-7136 
TUM Institution:
Institut für Allgemeine Pathologie und pathologische Anatomie