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Dokumenttyp:
journal article 
Autor(en):
Mangold, E; Pagenstecher, C; Friedl, W; Mathiak, M; Buettner, R; Engel, C; Loeffler, M; Holinski-Feder, E; Müller-Koch, Y; Keller, G; Schackert, HK; Krüger, S; Goecke, T; Moeslein, G; Kloor, M; Gebert, J; Kunstmann, E; Schulmann, K; Rüschoff, J; Propping, P 
Titel:
Spectrum and frequencies of mutations in MSH2 and MLH1 identified in 1,721 German families suspected of hereditary nonpolyposis colorectal cancer. 
Abstract:
Mutations in DNA MMR genes, mainly MSH2 and MLH1, account for the majority of HNPCC, an autosomal dominant predisposition to colorectal cancer and other malignancies. The evaluation of many questions regarding HNPCC requires clinically and genetically well-characterized HNPCC patient cohorts of reasonable size. One main focus of this multicenter study is the evaluation of the mutation spectrum and mutation frequencies in a large HNPCC cohort in Germany; 1,721 unrelated patients, mainly of Germa...    »
 
Zeitschriftentitel:
Int J Cancer 
Jahr:
2005 
Band / Volume:
116 
Heft / Issue:
Seitenangaben Beitrag:
692-702 
Sprache:
eng 
Print-ISSN:
0020-7136 
TUM Einrichtung:
r Allgemeine Pathologie und pathologische Anatomie