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Document type:
journal article 
Author(s):
Geddert, H; Kiel, S; Iskender, E; Florl, AR; Krieg, T; Vossen, S; Gabbert, HE; Sarbia, M 
Title:
Correlation of hMLH1 and HPP1 hypermethylation in gastric, but not in esophageal and cardiac adenocarcinoma. 
Abstract:
Using methylation-specific real-time PCR, we determined the prevalence of aberrant methylation in the mismatch repair gene hMLH1 and in the recently described HPP1 gene among 50 esophageal, 50 cardiac and 50 gastric ADCs. Additionally, expression of hMLH1 protein was detected immunohistochemically and correlated with DNA MSI. Hypermethylation of hMLH1 was found in 14% of esophageal, 28% of cardiac and 32% of gastric ADCs, whereas HPP1 hypermethylation was found more frequently in the 3 tumor typ...    »
 
Journal title abbreviation:
Int J Cancer 
Year:
2004 
Journal volume:
110 
Journal issue:
Pages contribution:
208-11 
Language:
eng 
Print-ISSN:
0020-7136 
TUM Institution:
Institut für Allgemeine Pathologie und pathologische Anatomie