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Document type:
journal article 
Author(s):
Vogt, S; Grosse, R; Schultz, G; Offermanns, S 
Title:
Receptor-dependent RhoA activation in G12/G13-deficient cells: genetic evidence for an involvement of Gq/G11. 
Abstract:
The small GTPase RhoA is involved in the regulation of various cellular functions like the remodeling of the actin cytoskeleton and the induction of transcriptional activity. G-protein-coupled receptors (GPCRs), which are able to activate Gq/G11 and G12/G13 are major upstream regulators of RhoA activity, and G12/G13 have been shown to couple GPCRs to the activation of Rho by regulating the activity of a subfamily of RhoGEF proteins. However, the possible contribution of Gq/G11 to the regulation...    »
 
Journal title abbreviation:
J Biol Chem 
Year:
2003 
Journal volume:
278 
Journal issue:
31 
Pages contribution:
28743-9 
Language:
eng 
Print-ISSN:
0021-9258 
TUM Institution:
die