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Dokumenttyp:
journal article 
Autor(en):
Drzezga, A; Becker, JA; Van Dijk, KR; Sreenivasan, A; Talukdar, T; Sullivan, C; Schultz, AP; Sepulcre, J; Putcha, D; Greve, D; Johnson, KA; Sperling, RA 
Titel:
Neuronal dysfunction and disconnection of cortical hubs in non-demented subjects with elevated amyloid burden. 
Abstract:
Disruption of functional connectivity between brain regions may represent an early functional consequence of ?-amyloid pathology prior to clinical Alzheimer's disease. We aimed to investigate if non-demented older individuals with increased amyloid burden demonstrate disruptions of functional whole-brain connectivity in cortical hubs (brain regions typically highly connected to multiple other brain areas) and if these disruptions are associated with neuronal dysfunction as measured with fluorode...    »
 
Zeitschriftentitel:
Brain 
Jahr:
2011 
Band / Volume:
134 
Heft / Issue:
Pt 6 
Seitenangaben Beitrag:
1635-46 
Sprache:
eng 
Print-ISSN:
0006-8950 
TUM Einrichtung:
Nuklearmedizinische Klinik und Poliklinik