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Document type:
journal article 
Author(s):
Seidl, C; Zöckler, C; Beck, R; Quintanilla-Martinez, L; Bruchertseifer, F; Senekowitsch-Schmidtke, R 
Title:
177Lu-immunotherapy of experimental peritoneal carcinomatosis shows comparable effectiveness to 213Bi-immunotherapy, but causes toxicity not observed with 213Bi. 
Abstract:
(213)Bi-d9MAb-immunoconjugates targeting gastric cancer cells have effectively cured peritoneal carcinomatosis in a nude mouse model following intraperitoneal injection. Because the ?-emitter (177)Lu has proven to be beneficial in targeted therapy, (177)Lu-d9MAb was investigated in this study in order to compare its therapeutic efficacy and toxicity with those of (213)Bi-d9MAb.Nude mice were inoculated intraperitoneally with HSC45-M2 gastric cancer cells expressing d9-E-cadherin and were treated...    »
 
Journal title abbreviation:
Eur J Nucl Med Mol Imaging 
Year:
2011 
Journal volume:
38 
Journal issue:
Pages contribution:
312-22 
Language:
eng 
Print-ISSN:
1619-7070 
TUM Institution:
Nuklearmedizinische Klinik und Poliklinik