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Dokumenttyp:
journal article 
Autor(en):
Gourni, E; Demmer, O; Schottelius, M; D'Alessandria, C; Schulz, S; Dijkgraaf, I; Schumacher, U; Schwaiger, M; Kessler, H; Wester, HJ 
Titel:
PET of CXCR4 expression by a (68)Ga-labeled highly specific targeted contrast agent. 
Abstract:
The overexpression of the chemokine receptor CXCR4 plays an important role in oncology, since together with its endogenous ligand, the stromal cell-derived factor (SDF1-?), CXCR4 is involved in tumor development, growth, and organ-specific metastasis. As part of our ongoing efforts to develop highly specific CXCR4-targeted imaging probes and with the aim to assess the suitability of this ligand for first proof-of-concept studies in humans, we further evaluated the new (68)Ga-labeled high-affinit...    »
 
Zeitschriftentitel:
J Nucl Med 
Jahr:
2011 
Band / Volume:
52 
Heft / Issue:
11 
Seitenangaben Beitrag:
1803-10 
Sprache:
eng 
Print-ISSN:
0161-5505 
TUM Einrichtung:
Nuklearmedizinische Klinik und Poliklinik