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Dokumenttyp:
journal article 
Autor(en):
Mertens, P; Maes, A; Nuyts, J; Belmans, A; Desmet, W; Esplugas, E; Charlier, F; Figueras, J; Sambuceti, G; Schwaiger, M; Mortelmans, L; Van de Werf, F 
Titel:
Recombinant P-selectin glycoprotein ligand-immunoglobulin, a P-selectin antagonist, as an adjunct to thrombolysis in acute myocardial infarction. The P-Selectin Antagonist Limiting Myonecrosis (PSALM) trial. 
Abstract:
BACKGROUND: Inflammatory responses induced by reperfusion of previously ischemic myocardial tissue may lead to further damage of the microvascular structures. A group of cell adhesion molecules, named selectins, initiate those inflammatory changes at the endothelial wall surface. Recombinant P-selectin glycoprotein ligand-immunoglobulin (rPSGL-Ig), a P-selectin antagonist, was shown to have beneficial effects in several animal models of acute myocardial ischemia. We performed a mechanistic study...    »
 
Zeitschriftentitel:
Am Heart J 
Jahr:
2006 
Band / Volume:
152 
Heft / Issue:
Seitenangaben Beitrag:
125.e1-8 
Sprache:
eng 
Print-ISSN:
0002-8703 
TUM Einrichtung:
Nuklearmedizinische Klinik und Poliklinik