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Dokumenttyp:
journal article 
Autor(en):
Bruus-Jensen, K; Poethko, T; Schottelius, M; Hauser, A; Schwaiger, M; Wester, HJ 
Titel:
Chemoselective hydrazone formation between HYNIC-functionalized peptides and (18)F-fluorinated aldehydes. 
Abstract:
INTRODUCTION: Since the demand for (18)F-fluorinated peptides for quantitative in vivo receptor imaging using PET has increased, a new chemoselective two-step (18)F-labeling strategy based on hydrazone formation between an unprotected hydrazine-functionalized peptide and an (18)F-labeled aldehyde was developed. METHODS: First, 4-[(18)F]fluorobenzaldehyde ([(18)F]FB-CHO) was prepared from 4-formyl-N,N,N-trimethylanilinium triflate via direct no-carrier-added (18)F-fluorination (dimethyl sulfoxide...    »
 
Zeitschriftentitel:
Nucl Med Biol 
Jahr:
2006 
Band / Volume:
33 
Heft / Issue:
Seitenangaben Beitrag:
173-83 
Sprache:
eng 
Print-ISSN:
0969-8051 
TUM Einrichtung:
Nuklearmedizinische Klinik und Poliklinik