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Dokumenttyp:
journal article 
Autor(en):
Haubner, R; Bruchertseifer, F; Bock, M; Kessler, H; Schwaiger, M; Wester, HJ 
Titel:
Synthesis and biological evaluation of a (99m)Tc-labelled cyclic RGD peptide for imaging the alphavbeta3 expression. 
Abstract:
AIM: The alphavbeta3 integrin is involved in tumour induced angiogenesis and tumour metastasis. We describe the synthesis and evaluation of a (99m)Tc-labelled RGD analogue for the visualisation of alphavbeta3 integrin expression. METHODS: The linear peptides were assembled on a solid support. Cyclisation was performed under high dilution conditions. For conjugation with the chelator peptide, a water soluble carbodiimide was used. Radiolabelling was carried out due to standard procedures with hig...    »
 
Zeitschriftentitel:
Nuklearmedizin 
Jahr:
2004 
Band / Volume:
43 
Heft / Issue:
Seitenangaben Beitrag:
26-32 
Sprache:
eng 
Print-ISSN:
0029-5566 
TUM Einrichtung:
Nuklearmedizinische Klinik und Poliklinik