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Document type:
journal article 
Author(s):
Schlossmann, J; Feil, R; Hofmann, F 
Title:
Insights into cGMP signalling derived from cGMP kinase knockout mice. 
Abstract:
cGMP signalling plays an important physiological role in diverse organs including the vasculature, the GI-tract and the nervous system. Furthermore, cGMP-elevating substances such as glyceryl trinitrate are important drugs used in cardiovascular diseases. Physiologically, cGMP synthesis is induced by nitric oxide (NO) and natriuretic peptides through the stimulation of guanylyl cyclases. Major mediators of cGMP signalling are the cGMP-dependent protein kinases type I and II (cGKI and cGKII). The...    »
 
Journal title abbreviation:
Front Biosci 
Year:
2005 
Journal volume:
10 
Pages contribution:
1279-89 
Language:
eng 
Print-ISSN:
1093-9946 
TUM Institution:
Institut für Pharmakologie und Toxikologie