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Dokumenttyp:
journal article 
Autor(en):
Sausbier, M; Hu, H; Arntz, C; Feil, S; Kamm, S; Adelsberger, H; Sausbier, U; Sailer, CA; Feil, R; Hofmann, F; Korth, M; Shipston, MJ; Knaus, HG; Wolfer, DP; Pedroarena, CM; Storm, JF; Ruth, P 
Titel:
Cerebellar ataxia and Purkinje cell dysfunction caused by Ca2+-activated K+ channel deficiency. 
Abstract:
Malfunctions of potassium channels are increasingly implicated as causes of neurological disorders. However, the functional roles of the large-conductance voltage- and Ca(2+)-activated K(+) channel (BK channel), a unique calcium, and voltage-activated potassium channel type have remained elusive. Here we report that mice lacking BK channels (BK(-/-)) show cerebellar dysfunction in the form of abnormal conditioned eye-blink reflex, abnormal locomotion and pronounced deficiency in motor coordinati...    »
 
Zeitschriftentitel:
Proc Natl Acad Sci U S A 
Jahr:
2004 
Band / Volume:
101 
Heft / Issue:
25 
Seitenangaben Beitrag:
9474-8 
Sprache:
eng 
Print-ISSN:
0027-8424 
TUM Einrichtung:
r Pharmakologie und Toxikologie; r Neurowissenschaften