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Dokumenttyp:
journal article 
Autor(en):
Auernhammer, CJ; Dorn, F; Vlotides, G; Hengge, S; Kopp, FB; Spoettl, G; Cengic, N; Engelhardt, D; Weber, MM 
Titel:
The oncostatin M receptor/gp130 ligand murine oncostatin M induces apoptosis in adrenocortical Y-1 tumor cells. 
Abstract:
The effects of murine oncostatin M (mOSM) are specifically mediated by the heterodimeric oncostatin M receptor (OSMR)/gp130 receptor complex. In the current study we demonstrate that murine adrenocortical Y-1 tumor cells express the OSMR/gp130 complex. Incubation of Y-1 cells with 1 and 10 ng/ml mOSM induces cell death due to specific induction of apoptosis. Western blot analysis of Y-1 cells incubated with mOSM for 24 h revealed caspase-3 cleavage and poly(ADP-ribase) polymerase (PARP) cleavage...    »
 
Zeitschriftentitel:
J Endocrinol 
Jahr:
2004 
Band / Volume:
180 
Heft / Issue:
Seitenangaben Beitrag:
479-86 
Sprache:
eng 
Print-ISSN:
0022-0795 
TUM Einrichtung:
r Neuroradiologie