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Document type:
journal article 
Author(s):
Läer, L; Kloppstech, M; Schöfl, C; Sejnowski, TJ; Brabant, G; Prank, K 
Title:
Noise enhanced hormonal signal transduction through intracellular calcium oscillations. 
Abstract:
In a wide range of non-linear dynamical systems, noise may enhance the detection of weak deterministic input signals. Here, we demonstrate this phenomenon for transmembrane signaling in a hormonal model system of intracellular Ca(2+) oscillations. Adding Gaussian noise to a subthreshold extracellular pulsatile stimulus increased the sensitivity in the dose-response relation of the Ca(2+) oscillations compared to the same noise signal added as a constant mean level. These findings may have import...    »
 
Journal title abbreviation:
Biophys Chem 
Year:
2001 
Journal volume:
91 
Journal issue:
Pages contribution:
157-66 
Language:
eng 
Print-ISSN:
0301-4622 
TUM Institution:
Abteilung für Neuroradiologie