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Dokumenttyp:
journal article 
Autor(en):
Henriksen, G; Platzer, S; Marton, J; Hauser, A; Berthele, A; Schwaiger, M; Marinelli, L; Lavecchia, A; Novellino, E; Wester, HJ 
Titel:
Syntheses, biological evaluation, and molecular modeling of 18F-labeled 4-anilidopiperidines as mu-opioid receptor imaging agents. 
Abstract:
The synthesis, evaluation, and molecular modeling of a series of 18F-labeled 4-anilidopiperidines with high affinities for the mu-opioid receptor (mu-OR) are reported. On the basis of the high brain uptake and selective retention in brain regions that contain a high concentration of the mu-OR, combined with a good metabolic stability, [18F]fluoro-pentyl carfentanil ([18F]4) and 2-(+/-)[18F]fluoropropyl-sufentanil ([18F]6) were selected as the lead compounds for further evaluation. The binding af...    »
 
Zeitschriftentitel:
J Med Chem 
Jahr:
2005 
Band / Volume:
48 
Heft / Issue:
24 
Seitenangaben Beitrag:
7720-32 
Sprache:
eng 
Print-ISSN:
0022-2623 
TUM Einrichtung:
Nuklearmedizinische Klinik und Poliklinik; Neurologische Klinik und Poliklinik