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Dokumenttyp:
journal article 
Autor(en):
Liebsch, R; Kornhuber, ME; Dietl, D; Gräfin von Einsiedel, H; Conrad, B 
Titel:
Blood-CSF barrier integrity in multiple sclerosis. 
Abstract:
INTRODUCTION: In about 20% of MS patients an increased CSF/serum albumin quotient (QAlb) has been observed. The reason for this blood-CSF barrier dysfunction is yet unclear. SUBJECTS AND METHODS: QAlb values from 48 MS patients in relapse were correlated with parameters of active CNS lesions as measured by gadolinium-DTPA MRIs. QAlb values from 20 MS patients without relapse served as controls. RESULTS: Mean QAlb values (x 10(3) of a group with spinal cord lesions (7.6 +/- 3.6; n = 16) differed significantly from those of a control group (4.6 +/- 1.5; n = 20; p< 0.005) as well as from those of a group with supratentorial lesions (5.0 +/- 1.8; n = 18; p< 0.05), and were higher than those of a group with infratentorial lesions (5.8 +/- 2.8; n = 14). QAlb values of patients with a spinal lesion tended to decrease with increasing time intervals between onset of relapse and lumbar puncture. CONCLUSION: The data is in consent with the present knowledge on flow dynamics of both extracellular fluid and CSF. As a clinical consequence, increased QAlb values in MS patients may hint at an active spinal or, less likely, infratentorial lesion. 
Zeitschriftentitel:
Acta Neurol Scand 
Jahr:
1996 
Band / Volume:
94 
Heft / Issue:
Seitenangaben Beitrag:
404-10 
Sprache:
eng 
Print-ISSN:
0001-6314 
TUM Einrichtung:
Neurologische Klinik und Poliklinik