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Dokumenttyp:
journal article 
Autor(en):
Eissler, R; Schmaderer, C; Rusai, K; Kühne, L; Sollinger, D; Lahmer, T; Witzke, O; Lutz, J; Heemann, U; Baumann, M 
Titel:
Hypertension augments cardiac Toll-like receptor 4 expression and activity. 
Abstract:
Hypertension causes cardiac hypertrophy characterized by low-grade inflammation. Toll-like receptors (TLRs), members of the innate immune system, contribute to cardiac failure. We hypothesized that hypertension is accompanied by enhanced TLR4 expression and activity. Cardiac TLR4 expression was determined in untreated spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto rats (WKY; 4, 8, 16 weeks). Besides, hearts of 8-week-old rats were stimulated with the endogenous TLR4 ligand...    »
 
Zeitschriftentitel:
Hypertens Res 
Jahr:
2011 
Band / Volume:
34 
Heft / Issue:
Seitenangaben Beitrag:
551-8 
Sprache:
eng 
Print-ISSN:
0916-9636 
TUM Einrichtung:
r Nephrologie